Department of internal diseases
8 7212 50-39-30, ext.1461
The Department of Internal Medicine has been the leader of the university for three years.
We teach you to recognize signs of diseases of internal organs, create an idea of the pathological process using cause-and-effect relationships, establish a diagnosis, find an acceptable solution in the treatment of pathology both on the basis of international recommendations and taking into account the individual characteristics of the patient.
The main scientific interests of the department are aimed at studying the features of pathogenesis, clinic, treatment and prevention of chronic non-communicable socially significant diseases of the cardiovascular, endocrine, respiratory, digestive, hematopoietic and urinary systems, rheumatological diseases, extragenital pathology in pregnant women, gerontology and geriatrics.
There are 49 teachers working at the department.
The science
The Department of Internal Medicine has a high scientific potential. More than half of the employees (56%) have a Hirsch index, up to a maximum of 5 points. The main scientific interests of the department are aimed at studying the features of pathogenesis, clinic, treatment and prevention of chronic non-communicable socially significant diseases of the cardiovascular, endocrine, respiratory, digestive, hematopoietic and urinary systems, rheumatological diseases, extragenital pathology in pregnant women, gerontology and geriatrics. The teaching staff actively conducts scientific research, the results of which are published in scientific indexed journals, and presented in the form of reports at national and international conferences.
The staff of the department are the authors of many textbooks, teaching aids for students and methodological recommendations for doctors.
The department pays great attention to the education of the future generation of doctors, where the priority is the preservation of traditions and the formation of cultural values.
The teaching staff actively conducts scientific research, the results of which are published in scientific indexed journals, and presented in the form of reports at national and international conferences.
"Erudites of Therapy" – Student scientific circle of the Department of Internal Medicine
Community members conduct scientific clinical research, master the necessary practical, laboratory skills to set research material, master the basics of statistics to analyze their own data. The forms of work of the SNK are: a magazine club, a school of a young internist, at the meetings of the circle discussion of the preparation of publications and reports on topical topics of students' research work.
Research areas: pathogenetic significance of structural and functional imbalance in diseases of human internal organs (cardiovascular, respiratory, endocrine, digestive, hematopoietic, urinary, musculoskeletal and immune systems).
The main directions of scientific activity:
- Clinical and pathogenetic, diagnostic and therapeutic aspects in diseases of internal organs;
- Extragenital pathology in pregnant women;
- Molecular genetic predictors of the development of chronic diseases;
- The metabolome and microbiome of the intestine;
- Research in the field of medical education.
The most significant research projects of the department:
- A personalized approach to the management of a number of significant diseases. Head: MD, Professor Taizhanova D.J. Deadlines: 2018-2020. The aim of the work is to develop scientific foundations for a personalized approach to the management of a number of significant diseases based on the molecular genetic characteristics of patients.
- Assessment of the genetic polymorphism of CYP2C19 in Kazakh people taking clopidogrel after coronary artery stenting. Head: MD, Professor Taizhanova D.J. Deadlines: 2019-2021. The aim of the work was to evaluate the genetic polymorphism of CYP2C19 in Kazakh people taking clopidogrel after coronary artery stenting.
- COVID-19: Scientific and technological justification of a response system to the spread of new respiratory infections, including the coronavirus infection. Task supervisor: Senior Researcher E.M. Laryushina. Project duration: 2021-2023. As part of this project, the department's staff studied the clinical manifestations, complications, early and long-term outcomes, and developed models for predicting disease outcomes and algorithms for diagnosing the novel coronavirus infection.
- Study of the association between TMAO and LPS-binding protein levels and the activity of inflammatory bowel diseases. Supervisor: Head of the Department, PhD in Medicine, Professor E.M. Laryushina. Project duration: 2022-2024. The aim of this project is to study the levels of trimethylamine N-oxide and lipopolysaccharide-binding protein in the blood of patients with inflammatory bowel diseases as a potential marker of disease activity.
- Pathogenetic significance of the structural and functional imbalance of the vascular system in the pulmono-cardio-renal continuum. Supervisor: Doctor of Medical Sciences, Professor L.K. Ibraeva. Project duration: 2023-2025. The aim of the project is to study the structural and functional imbalance of the vascular system from the perspective of improving the pathogenetic mechanisms of the pulmono-cardio-renal continuum.
The most important publications of the department's staff:
- Genetic Predictors of the Development of Complications after Coronary Stenting. Dana Taizhanova, Akerke Kalimbetova, Roza Bodaubay et all. Pers. Med. 2023, 13, 14.
- Genetic markers of the risk of coronary heart disease and coronary artery thrombosis developing in the Kazakh population. Dana Taizhanova, Aliya Toleuova, Dmitry Babenko, Anar Turmuhambetova, Roza Bodaubay, Olga Visternichan, Akerke Kalimbetova / Caspian Journal of Internal Medicine. 2023; 14(2): 249-256 DOI: 10.22088/cjim.14.2.249.
- Nonlinear analyses of heart rate variability in hypertension | Analyse non linéaire de la variabilité du rythme cardiaque en hypertension artérielle. Annales de Cardiologie et d'Angeiologie, 2018, 67(3), P. 174–179 Koichubekov, B.K., Sorokina, M.A., Laryushina Y., Turgunova, L.G., Korshukov, I.V.
- Relationship between trimethylamine n-oxide and total cardiovascular risk in the population of central Kazakhstan. Аcta Medica Mediterranea 2018, 34: 59 Мarchenko Alexandr Borisovich, Ivasenko Svetlana Aleksandrovna, Laryushina Y., Turgunova Lyudmila Gennadievna, Turmukhambetova Anar Akylbekovna, Dan Moraru, Antonella Chesca
- Association of Plasminogen Activator Inhibitor-1 and Cardiovascular Events Development in Patients with Prediabetes. Yelena Laryushina, Viktoriya Parakhina, Lyudmila Turgunova, Dinara Sheryazdanova1, Raushan Dosmagambetova, Anar Turmukhambetova, Olga Ponamareva, Maria Orbetzova. Open Access Macedonian Journal of Medical Sciences. 2021 Aug 28; 9(B):726-733.
- Association between 1,5-anhydro-D-sorbitol, Insulin, and Incretins in Patients with Pre-diabetes and ST-elevation Myocardial Infarction. Dinara Sheryazdanova, Yelena Laryushina, Natalya Vassilyeva, Aigul Serikbayeva, Assel Alina, Maria Butyugina, Zauresh Tauesheva. Open Access Macedonian Journal of Medical Sciences. 2022 Mar 01; 10(B):464-469.
- Turgunova L.; Mekhantseva I.; Laryushina Y.; Alina A.; Bacheva I.; Zhumadilova Z.; Turmukhambetova A. The Association of Endothelin-1 with Early and Long-Term Mortality in COVID-19 // J. Pers. Med. 2023, 13, 1558.
The result of the research activities of the staff includes innovative research methods and developments:
- Algorithms for managing cardiovascular disease risk factors. A.A. Turmukhambetova, L.K. Ibraeva, L.G. Turgunova, E.M. Laryushina, I.V. Bacheva, B.K. Omarkulov, T.O. Abugalieva, F.U. Nildibaeva, D.N. Sheryazdanova, A.A. Shalygina, D.E. Tulegenova (Guidelines), 2018 - 39 pages.
- Method for quantitative determination of trimethylamine N-oxide levels in blood plasma, printed, Marchenko A.B., Ivasenko S.A., Turmukhambetova A.A. (Patent No. 33624, registered in the State Register of Inventions of the Republic of Kazakhstan on 04.05.19).
- Questionnaire for assessing risk factors in atrial fibrillation, D.Zh. Taizhanova, R.B. Bodaubai, A.B. Kalimbetova, N.K. Bazarova. (Certificate of entry of information into the state registration of rights for objects protected by copyright No. 13249, 16.11.2020).
- Model for assessing the probability of endothelial dysfunction in patients at high risk of type 2 diabetes. V.F. Parakhina, E.M. Laryushina, F.U. Nildibaeva. (Copyright object No. 14821, dated 02.02.2021, Ministry of Justice of the Republic of Kazakhstan, 02.02.2021).
- Model for calculating the risk of developing diabetes using the FINDISK scale, postprandial glycemic variability indicators, and insulin resistance. D.N. Sheryazdanova, E.M. Laryushina, A.B. Marchenko. (Copyright object No. 14942, dated 08.02.2021, Ministry of Justice of the Republic of Kazakhstan).
- Method for treating seasonal allergic rhinitis using allergen-specific immunotherapy in conjunction with vitamin D. M.R. Izmailovich, M.A. Gazalieva, N.E. Glushkova. (Copyright object No. 14750, dated 29.01.2021, Ministry of Justice of the Republic of Kazakhstan, 29.01.2021).
- Algorithm for predicting new cardiovascular events after percutaneous coronary intervention, D.Zh. Taizhanova, R.B. Bodaubai, A.B. Kalimbetova. (Certificate of entry of information into the state registration of rights for objects protected by copyright No. 31084, dated 14.12.2022).
- Program for the diagnosis and rehabilitation of post-COVID syndrome, Turmukhambetova A.A., Laryushina E.M., Ibraeva L.K., et al. // Guidelines. Karaganda, 2023. - 68 pages.
Education
We teach students to recognize the signs of diseases of the internal organs, to form an understanding of the pathological process using causal relationships, to establish a diagnosis, and to find acceptable treatment solutions based on international guidelines as well as considering the individual characteristics of the patient.
The faculty of the department has extensive experience in training bachelors, interns, residents, and physicians, generously imparting knowledge, skills, and expertise.
The department's instructors possess innovative teaching methods aimed at fostering and developing clinical thinking in students, encouraging independent information-seeking, teamwork skills, and decision-making in patient management, as well as developing leadership qualities, initiative, and creative potential. The learning process primarily emphasizes practice-oriented education (learning 'at the bedside'), and actively employs methods such as problem-based lectures, practical classes using PBL, TBL, CBL, RBL methodologies, as well as distance learning, interdisciplinary approaches, simulation technologies, and more.
An integral part of student life is participation in campaigns for the prevention and early diagnosis of chronic diseases of the internal organs.
Under the guidance of the department's instructors, students actively participate in volunteer movements, providing consulting and charitable assistance at the 'Miloserdiye' home for the disabled and elderly in Karaganda, as well as in shelters for homeless animals.
Clinic
The faculty of the Department of Internal Medicine has extensive clinical experience. Ninety-eight percent of the instructors have more than five years of work experience and are physicians of various therapeutic specialties (allergology and immunology, gastroenterology, hematology, cardiology, nephrology, pulmonology, rheumatology, therapy, and endocrinology) as well as pediatrics (allergology and immunology, cardiology). With a high level of medical qualification, the instructors provide significant consultative, diagnostic, and expert assistance to the healthcare system of Karaganda region and the Republic, and they are developers of clinical protocols and professional standards.
The following developments have been implemented in clinical practice by the department staff:
- Algorithms for Managing Cardiovascular Disease Risk Factors. L.K. Ibraeva, L.G. Turgunova, E.M. Laryushina, I.V. Bacheva, F.U. Nildibaeva, D.N. Sheryazdanova, A.A. Shalygina, D.E. Tulegenova.
- Diagnosis and Therapeutic Tactics for the Association of Cardiovascular Diseases with COVID-19. D.Zh. Taizhanova, R.B. Bodaubai, A.B. Kalimbetova.
- Assessment of the Risk of Complications During Dual Antiplatelet Therapy in Patients with Cardiovascular Diseases. D.Zh. Taizhanova, R.B. Bodaubai, A.B. Kalimbetova.
- Calculator for Assessing the Risk of Cardiovascular Events in Patients with Type 2 Diabetes Based on Postprandial Glycemic Variability and Insulin Resistance Indicators. E.M. Laryushina, D.N. Sheryazdanova.
- Program for the Diagnosis and Rehabilitation of Post-COVID Syndrome, Turmukhambetova A.A., Laryushina E.M., Ibraeva L.K., et al.
- Questionnaire for Studying the Impact of Non-Ionizing Radiation on the Health of Medical Personnel. Ibraeva L.K., Rybalikina D.Kh., Bacheva I.V., et al.
- Ergonomics of Workplaces and Hygienic Safety of Working Conditions for Medical Specialists in Radiology Departments (MRI and Ultrasound). Ibraeva L.K., Rybalikina D.Kh., Bacheva I.V., et al.
Lectures and Master Classes as Part of the 'Visiting Professor' Program:
- T.V. Vavilova - Doctor of Medical Sciences, Professor at the Federal State Budgetary Institution 'NMIC named after V.A. Almazov' (St. Petersburg, Russia) 'Course on Hemostasiology'.
- K.K. Esmebetev - Candidate of Medical Sciences, Professor at the University Clinic in Aachen, Germany, 'Hepatology Course' with a Master Class on Ultrasound Diagnosis of Liver Diseases.
- Leila Temurovna Akhvlediani - Professor at the Medical Faculty of Batumi International University (Georgia), Dean of the Medical Faculty at Batumi International University, Professor at Shota Rustaveli State University - Course on 'Immunology'.
- I.S. Azizov - Doctor of Medical Sciences, Professor, Head of the Laboratory Complex at the Research Institute of Antimicrobial Chemotherapy, Smolensk, Training Seminar on Antimicrobial Chemotherapy.
Teachers
Scientific degree: Candidate of Medical Sciences
Position: Associate Professor
Scientific degree: Candidate of Medical Sciences
Position:Associate Professor
Academic degree: Doctor of Medical Sciences
Academic title:Professor
Scientific degree: Master's degree in Medicine
Position: Assistant Professor
8 7212 50-39-30
Academic degree: Candidate of Medical Sciences
Position: Associate Professor
Academic degree: Candidate of Medical Sciences
Position : Professor
Academic degree : Candidate of Medical Sciences
Position : Associate Professor
Academic degree: Doctor of Medical Sciences
Position: Professor
+7 7212 503930, ext.1475
Academic degree : Candidate of Medical Sciences of the Russian Federation
Position: Professor
Academic degree : Candidate of Medical Sciences
Position : Associate Professor
+7 7212 503930
Academic degree :Candidate of Medical Sciences
Position :Professor
Academic degree: Master of Medical Sciences
Position :Assistant Professor
Academic degree: Doctor of Medical Sciences
Academic title: Professor
+7 7212 503930, int. 1461
History of the Department
The Department of Internal Medicine was established as a result of the consolidation of three previously independent departments of Internal Medicine No. 1, No. 2, No. 3, and the course on Clinical Immunology and Allergology. Each unit underwent individual periods of formation and development. The latest period of development for the Department of Internal Medicine began on September 1, 2020, when a single Department of Internal Medicine was formed as a result of the reorganization of the three divisions and the course on Clinical Immunology and Allergology.
Department of Internal Medicine No. 1 has its history dating back to 1952. The department was established at the Karaganda Regional Hospital, and the first head was Associate Professor A.V. Ivanova. From 1970, the department was successively led by Associate Professor M.Sh. Tastambekova, Professor N.I. Albertov, V.M. Chernousov, Professor S.A. Baydurin, Associate Professor M.Ya. Falikovich, and Doctor of Medical Sciences R.A. Omarova. The traditions of the department were enriched by outstanding educators, clinicians, scientists, and healthcare organizers: Professor T.Z. Seisembekov, who trained 10 doctors and 35 candidates of sciences, served for many years as the Vice-Rector for Scientific Work and the Director of the Cardiology Research Institute in Astana; E.A. Abzhanov, who headed the cardiology service in the region; and Professor N.I. Albertov, who continued educational activities and led the therapeutic service in Israel. Doctoral dissertations were defended, and heads of departments at universities in Kazakhstan were produced by: Professor N.S. Umbetalyina, Professor K.A. Alikhanova, and Professor S.A. Baydurin. Throughout the years, the department employed candidates of medical sciences A.E. Dronova, V.P. Zavadsky, V.M. Chernousov, E.S. Seitenov, B.S. Kan; A.I. Balyagina, A.F. Galina, V.N. Sapozhkov; assistants E.P. Leshina, V.G. Nedovesova, and A.F. Karavai. From 2002 to September 2020, the department was led by an outstanding scholar, clinician, educator, and leader - Doctor of Medical Sciences, Professor D.J. Taiyanova.
Department of Internal Medicine No. 2 formerly the Department of Hospital Therapy) was established in 1953. It was led by the legendary cohort of physician-scientists, with the first head of the department being Professor E.I. Tsukershtein (1953-1962), who established high-quality medical education as a principle. The foundational principles of working with students and patients, as well as scientific activities, were inherited by successive generations of leaders, each of whom made invaluable contributions to the department’s development, placing it among the flagship institutions of medical education. From 1963 to 1987, the department was headed by Professor K.Z. Tnimova. In 1971, the Department of Hospital Therapy No. 2 was established, led by Professor V.M. Karlinsky. The Department of Hospital Therapy No. 1 was successfully headed by Associate Professor L.K. Badina from 1987 to 1996. New challenges of the time necessitated the merging of departments during the difficult period of Kazakhstan's independence. The leadership of the Department of Hospital Therapy, subsequently known as the Department of Internal Diseases No. 2, was carried out by Doctor of Medical Sciences, Professor N.S. Umbetalina starting in 1996. From 2003 to 2012, the department was led by Doctor of Medical Sciences, Professor R.D. Konakbaeva. From March 2012 to September 1, 2014, the department was headed by Doctor of Medical Sciences, Professor L.G. Turgunova. Since September 1, 2014, the head of the department has been appointed to Candidate of Medical Sciences, Associate Professor E.M. Laryushina. The proclaimed principles of preserving traditions, implementing innovations, and passing down the spirit of leadership from generation to generation are realized by the department's staff to this day.
Department of Internal Medicine No. 3 was established in 2005 as part of the Faculty of Postgraduate Education and Continuous Professional Development. It is associated with the name of the outstanding therapist, Doctor of Medical Sciences, Professor N.S. Umbetalina, who served as its unwavering leader for ten years. From 2015, the department was led by Doctor of Medical Sciences, Professor L.G. Turgunova. From 2017 until early 2020, it was headed by Doctor of Medical Sciences, Professor L.K. Ibraeva. Among the initial staff members of the department were Candidate of Medical Sciences, Associate Professor T.K. Dyusembayeva and Candidate of Biological Sciences Sh.E. Dikanbaeva. Over the years, the department has seen contributions from several notable figures, including Professor R.M. Abdullabekova, Doctor of Medical Sciences, Professor L.G. Turgunova, Doctor of Medical Sciences, Professor R.A. Omarova, Professor N.I. Sheveleva, Doctor of Medical Sciences, Professor A.M. Bukenov, Doctor of Medical Sciences, Professor K.J. Musulmanbekov, Candidate of Medical Sciences, Associate Professor G.T. Igimbayeva, Candidate of Medical Sciences, Associate Professor E.V. Krug, Associate Professor N.N. Rechenskaya, Candidate of Medical Sciences J.S. Kyzylova, Candidate of Medical Sciences D.T. Amirkhanova, Candidate of Medical Sciences A.B. Skakova, Candidate of Medical Sciences G.K. Magzumov, and assistants N.N. Sedach, J.S. Yerzhanova, and S.V. Volokitin. The department has been significantly enriched by the contributions of highly qualified specialists, such as Professor R.S. Dosmagambetova (now the Rector of the Karaganda Medical University), Professor N.S. Umbetalina, Associate Professor L.K. Badina, Professor R.D. Konakbaeva, Professor D.Zh. Taizhanova, Professor M.M. Tusupbekova, Professor T.M. Majitov, Professor S.B. Zhautykova, and Associate Professor M.T. Aitkulov.
Initially, the allergy course was established within the Department of Occupational Diseases in 1990. Over the years, the course in clinical immunology and allergy was associated with various departments, including those of Occupational Hygiene and Occupational Diseases, Endocrinology and Allergy, Infectious Diseases, Oncology, Immunology, and Phthisiatry. Since 2002, it has been part of the Department of General and Clinical Immunology with Microbiology. The course was headed by Associate Professor G.A. Sagatova, Professor A.K. Badina, Associate Professor V.N. Snopkov, Doctor of Medical Sciences, Professor N.V. Kozachenko, Doctor of Medical Sciences, Professor S.B. Akhmetova, and Candidate of Medical Sciences, Associate Professor N.A. Timchenko. In 2013, by order of the rector of Karaganda Medical University, the course was transformed into the Department of Clinical Immunology and Allergy, which was led until 2019 by Doctor of Medical Sciences, Professor M.A. Gazalieva. She currently serves as the Vice-Rector for Clinical Affairs at the National Autonomous Organization "Medical University of Astana."
