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Scientific and technical programs of «MUK» NCJSC
Scientific and technical programs of «MUK» NCJSC

Ministry of Health of the Republic of Kazakhstan (program funding)

Scientific and technical program O.0769 "Development of the scientific basis for the formation of a preventive environment in order to preserve public health"

Term of execution- 2017-2019.

Supervisor– Doctor of Medical Sciences, professor R. Dosmagambetova.

State registration No.  0117RK00018

Collaborators:

National Center of Public Health, Research Institute of Cardiology and Internal Diseases, Kazakh Order “Sign of Honor” Research Institute of Eye Diseases, Scientific Center of Pediatrics and Pediatric Surgery.

The objective of the program is the development of science-based technologies for the formation of a preventive environment and the promotion of public health.

Tasks:

1.  Development and improvement of technologies to influence managed risk factors of cardiovascular diseases at the primary health care level

2.  Development of evidence-based recommendations for optimizing the school environment for the preservation and strengthening of children's health

3.  Development of technologies for the assessment and management of occupational risks of health problems in the mining and energy industries

Scientific and technical program O.0772 "Development of scientific and methodological foundations for minimizing the environmental burden, medical support, social protection and health improvement of the population in environmentally unfriendly territories of the Republic of Kazakhstan"

Term of execution- 2017-2019.

Supervisor– Doctor of Medical SciencesE. Zhunusov.

Collaborators:

"West Kazakhstan Medical University named after Marat Ospanov" NCJSC, "Medical University Astana" NCJSC, Research Institute of Radiation Medicine and Ecology.

The objective of the program is to develop a strategy of methodological approaches for medical support, social protection and rehabilitation of the population of Kazakhstan by minimizing the medical, psychological and social consequences of man-made and environmental risk factors.

Tasks:

1.  Assessment of the amount and nature of negative technogenic and environmental risk factors with the ranking of the study areas according to the degree of environmental risk.

2.  A comprehensive description of the health status of the population living in conditions of the influence of radiation and non-radiation risk factors; development of a model for assessing the incidence in the studied regions.

3.  Analysis of the socio-economic status of territories with different levels of radiation and non-radiation risk.

4.  Assessment of the psychological state of the population living in ecologically unfavorable territories, and the system of medical and psychological protection from inadequate information on the effect of radiation and non-radiological risk factors on health status.

5.  Development of algorithms for rehabilitation programs for medical, socio-psychological protection of the population of environmental risk areas, schemes for the prevention and rehabilitation of oil and gas workers. Preparation of proposals on making additions and changes to the legislative acts of the Republic of Kazakhstan on issues of medical and social protection of the population, justification of environmental risk zones.

Committee of the Ministry of Education and Science of Kazakhstan (program and target financing)

Scientific and technical program О.0821 «Personalized approach in the management of a number of significant diseases»

Term of execution - 2018-2020 years

Supervisor – Doctor of Medical Sciences A. Turmukhambetova

State registration No. 0118РК01034

Collaborators:

"Hospital of the Medical Center for Administration of Affairs of the President of the Republic of Kazakhstan" RSE.

The objective of the program is development of a scientific basis for a personalized approach in the management of a number of significant diseases based on the molecular genetic characteristics of patients.

Tasks:

1.  Search and estimation of the biomarkers associating with colorectal cancer among the representatives of the main ethnic groups of Kazakhstan.

2.  The development of personalized approaches in colorectal cancer chemotherapy.

3.  Search and evaluation of the main genetic markers of resistance to antiplatelet therapy in patients with coronary heart disease among representatives of the main ethnic group of Kazakhstan.

4.  Study of genetic determinants associated with remodeling of the cardiovascular system.

Committee of the Ministry of Education and Science of RK (grant financing of scientific researches)

1.  Development and use of the allograft impregnated with antibiotic, prepared according to the Marburg system of the bone bank for the treatment of osteomyelitis.

Research supervisor – Doctor of Medicine, professor B. Tuleubayev (2018-2020, No. SR 0118RK01020);

2.  Assessment of occupational risks and health status of persons working in the mining industry of Central Kazakhstan.

Research supervisor – Doctor of Medicine, professor E. Sraubaev (2018-2020, No. SR 0118RK01016);

3.  Application of extracellular matrix xenobrain in reconstructive surgery and operative urology.

Research supervisor – Candidate of Medical Sciences, N. Abatov (2018-2020, No. SR 0118RK01010);

4.  Clinico-physiological basis for the early diagnosis of pulmonary hypertension in infants.

Research supervisor – Doctor of Medicine, professor F. Mindubaeva (2018-2020, No. SR 0118RK01015);

5.  Complex assessment of the phenomenon of bacterial translocation in tissues, internal organs and systemic blood flow on models of intestinal obstruction.

Research supervisor – Doctor of Medicine, professor E. Turgunov (2018-2020, No. SR 0118RK01018).

Economic contractual themes

1.  Study in accordance with Record No. M14-465 "Randomized, double-blind phase III study to compare ABT-494 with placebo in patients with moderate or severe active rheumatoid arthritis who receive standard basal antirheumatic drugs at a stable dose and which have not reached adequate response to them". (Customer - OOO" EbbVie", Moscow).

Research supervisor – Candidate of Medical Sciences, Associate Professor A. Alina.

2.  Study under Record No. M13-545 "Randomized, double-blind phase III study to compare ABT-494 with placebo in patients with moderate to severe severe rheumatoid arthritis who receive standard basal antirheumatic drugs at a stable dose and have not reached adequate response to them". (Customer - OOO" EbbVie", Moscow).

Research supervisor – Candidate of Medical Sciences, Associate Professor A. Alina.

3.  Randomized placebo-controlled studies of the safety, therapeutic effectiveness of the oral form of the drug FS-1 in the resistant forms of pulmonary tuberculosis. (Customer - Joint Stock Company "Scientific Center of Anti-Infective Drugs", Almaty).

Research supervisor – Doctor of Medicine, professor N.Tabriz

4.  A randomized open clinical trial of the efficacy and safety of Sausalin in comparison with Orniside in the treatment of patients with lyabliasis (Customer is JSC International Scientific and Production Holding Phytochemistry).

Research supervisor – Doctor of Medicine,professor R. Begaydarova

5.  An open, blinded, randomized, controlled study of the efficacy and safety of using Reosorbilact®, solution for infusions (Yuriya-Farm, Ukraine), in comparison with Ringer-lactate, solution for infusions in the complex treatment of patients with burns disease (Customer - Cromos Pharma LLC).

Research supervisor – Doctor of Medicine B. Tuleubaev.

6.  A multicenter clinical study of the original drug "Arglabin" in the complex therapy of breast cancer in high doses (Customer - JSC MNPH Phytochemistry, Karaganda).

Research supervisor – Doctor of Medicine, professor V. Syrota.

Initiative Topics

1.  Vesiculogenesis and neutrophil reactivity with acute kidney damage.

Research supervisor– Doctor of Medical Sciences, professor V. Molotov-Luchansky.

2.  Development of a new method for the synthesis of polylactic acid under microwave activation and 3D printing of medical products based on it.

Research supervisor– Doctor of Chemistry, professor D. Khrustalev.

3.  Search for resistance mechanisms in microorganisms isolated from domestic animals in Karaganda.

Research supervisor – PhD I. Belyaev

4.  The study of medical literacy of young people in Karaganda to develop evidence-based recommendations for improving health promotion programs and the formation of a healthy lifestyle for the population.

Research supervisor– Candidate of Medical Sciences S. Zhakenova.

5.  Clinical and biochemical aspects of the formation, progression and leveling of cognitive deficit in patients with arterial hypertension who have undergone transient-ischemic attack.

Research supervisor– Candidate of Medical Sciences R. Toyynbekova.